Disruption Beads

Disruption beads are used for homogenizing, grinding, and disintegrating samples using a bead beater. These beads come prefilled in 2mL tubes with screw cap microvials for use with most bead beaters; acid washed and heat treated prior to sale to remove contaminants and render them nuclease free.

Zirconia silica beads with an average particle diameter of 0.1mm are an excellent way to treat bacteria, fungi, yeast and most tissues. Furthermore, these more dense media improve mill performance.

High Purity

Glass beads, zirconium powder and stainless steel can all effectively disrupt cells and tissues; however, denser silica and zirconia materials produce greater yields of homogenized material due to their greater density, as well as being better at penetrating tougher tissues types.

Zirconia silica beads produced using high grade, yttria stabilized zirconia powder are chemically co-precipitated for uniformity and consistency during high energy milling processes, producing media with extremely low wear rates that resist contamination during milling operations.

Alcohol washed and heat treated beads are prefilled to eliminate contaminants while simultaneously rendering them nuclease- and protease-free, making them suitable for numerous applications and size ranges. TriplePure Zirconium Bead Kits come prefilled for your convenience with five bead sizes to homogenize everything from bacteria to large tissue samples.

Pharmaceutical and biotechnology companies, research universities, hospitals, government labs and more use these media products. They’re an essential element in conducting viral pathogen studies such as those for herpes simplex virus (HSV), influenza virus, human immunodeficiency virus (HIV) and HIV research; plus hundreds of laboratory facilities worldwide use MSE PRO(tm) brand bead beaters which use this media as part of their bead beater systems – more information can be found on its product webpage; MSE PRO(tm) trademark owned by MSE Supplies Inc.

High Density

Glass (silica) beads, zirconium beads and stainless steel homogenizer media all perform effectively at disrupting cells and tissues; however, those working with particularly tough or fibrous samples often find better results using denser beads. A researcher from Health & Science University recently reported that whole organs cut into 1mm cross-section pieces were homogenized using 1.0 mm zirconia sharp particles in a Mini-Bead Beater at ambient or cryo temperatures using this approach; previously pre-chopping or cryopulverization were necessary to completely homogenize these tissues before this method could even begin working – similar results were seen with pre-chopping or cryopulverization being necessary before this was possible with no pre-chopping necessary prior.

Zirconia silicate beads offer higher densities than glass beads, making them suitable for handling spores and many harder samples. Zirconium beads have also proven resistant to fragmentation while being chemically inert; furthermore, their ceria stabilized zirconium composition provides resistance against proteases and nucleases degradation as well as reduced mill wear compared to other sharp particle types.

Garnet is another sharp bead product we carry, an iron-aluminum silicate material with a density of 4.1 g/cc. However, unlike alumina it is not chemically inert and will readily fragment during beadbeating; however this feature makes it especially helpful in cases of samples containing bacteria as its fragments speed up their lysis process. Both materials come in both pressed and spherical shapes, provided in acid washed, sterilized 96 well microplates to ensure optimal performance.

High Wear Resistance

Zirconia Silicate beads are an ideal choice for many grinding processes, from attritors and ball mills to basket mills and high-speed agitation mills. Their high wear resistance helps lower media disposal costs compared to chrome steel media; additionally they’re better suited to water-based processes than other media which may discolor solutions.

Zirconia Silicate beads undergo an exhaustive production process in order to guarantee their quality. Once formed, these beads pass through a selection machine which removes any misshapen or defective media before being sent for final baking in an industrial kiln – ultimately producing high-grade Zirconia Silicate beads with superior wear resistance.

Finishing zirconia silicate beads not only removes any misshapen or defective media, but it also gives them hardness and toughness – ideal characteristics for grinding and dispersing many chemical products, or applications where contamination could be an issue such as pharmaceuticals or food production.

Zirconia/silica beads’ middle density makes them an excellent replacement for glass in most conventional milling machines, especially when working with bacteria, yeast and most tissue homogenization. When working with tough or fibrous tissue it may be best to use more dense bead material – such as our special 2 mL and 7 mL screw-cap microvials – which will disrupt spores more effectively while extracting tougher tissues more thoroughly.

High Fracture Toughness

Titanium and its alloys have long been the go-to material for orthopaedic implants and dental restorations, yet zirconia (ZrO2) has quickly gained ground due to its superior biocompatibility, corrosion resistance and mechanical properties; specifically its higher mechanical strength and fracture toughness than titanium alloys.

Furthermore, its superior fatigue resistance allows it to withstand the repeated loading and unloading forces experienced in oral functions. In addition, its chemical stability is key as oral environments often experience pH fluctuations and corrosion from acidic substances; finally it boasts good dimensional stability to ensure its shape remains unaltered and fit is maintained over time.

Mechanical characteristics of dental zirconia remain to be fully optimized and understood, which has necessitated extensive investigation of its critical mechanical characteristics and performance as well as future directions of research. In this paper, an in-depth exploration is provided of their fundamental attributes with a particular emphasis on research challenges and future directions.

Biaxial tests were used to compare the flexural strengths of as-sintered and post-sandblast Y-TZP bars using biaxial tests. No significant difference in strength could be detected between as-sintered and post-sandblasted specimens, although when packed with Clearfil Esthetic cement these samples displayed significantly increased flexural strengths when compared with Cercon, IZ, or Empress 2 primers; likely caused by interactions between their hydrophobic surface of Y-TZP with its hydrophobic silica content while almost identical surface profiles across these three ceramics also displayed almost identical sorption/chemical solubility as functions of silica content indicating potential interactions among ceramic surfaces between themselves despite differing silica content among these samples